Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa.

@article{Gabrovsek2004CombinedFT,
  title={Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa.},
  author={Mojca Gabrovsek and Maria Brecelj-Anderluh and Laura Bellodi and Elena Cellini and Daniela J Di Bella and Xavier Estivill and Fernando Fern{\'a}ndez-Aranda and Beane Freeman and Frank Geller and M{\'o}nica Gratac{\'o}s and Rex Haigh and Johannes Hebebrand and Anke Hinney and J Holliday and Xianzhang Hu and Andreas Karwautz and Benedetta Nacmias and Marta Ribas{\'e}s and Helmut Remschmidt and Radovan Komel and Sandro Sorbi and Martina Tomori and Janet Treasure and Gudrun Wagner and Jingping Zhao and David A. Collier},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2004},
  volume={124B 1},
  pages={
          68-72
        }
}
The high activity Val158 (H) allele of the dopamine-metabolizing enzyme catechol-O-methyltransferase (COMT) was associated with anorexia nervosa (AN) in a recent family trio-based study of patients from Israel. In an attempt to replicate this finding, we performed a combined family trio and case-control study in an European population from seven centers in six different countries (Austria, Germany, Great Britain, Italy [Milan], Italy [Florence], Slovenia, and Spain), together contributing a… CONTINUE READING

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