Combined factor VIII/factor XI deficiency may cause intra-familial clinical variability in haemophilia A among Ashkenazi Jews.

@article{Berg1994CombinedFV,
  title={Combined factor VIII/factor XI deficiency may cause intra-familial clinical variability in haemophilia A among Ashkenazi Jews.},
  author={Linnea Berg and David Varon and Uri Martinowitz and Kerstin Wieland and Vijay Vir Kakkar and David N. Cooper},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={1994},
  volume={5 1},
  pages={59-62}
}
Heterozygous factor XI deficiency occurs very frequently among Ashkenazi Jews. To investigate the potential influence of a co-inherited factor XI deficiency state on the clinical phenotype of mild/moderate haemophilia A, 28 unrelated haemophiliacs of Jewish origin were screened for the two most common factor XI gene mutations. Gene lesions were identified… CONTINUE READING