Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats.

@article{Jacobsen2010CombinedET,
  title={Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats.},
  author={Pernille Rosenskjold Jacobsen and Sofie Christiansen and Julie Boberg and Christine Nellemann and Ulla Hass},
  journal={International journal of andrology},
  year={2010},
  volume={33 2},
  pages={434-42}
}
Risk assessment is currently based on the no observed adverse effect levels (NOAELs) for single compounds. Humans are exposed to a mixture of chemicals and recent studies in our laboratory have shown that combined exposure to endocrine disrupters can cause adverse effects on male sexual development, even though the doses of the single compounds are below their individual NOAELs for anti-androgenic effects. Consequently, we have initiated a large project where the purpose is to study mixture… CONTINUE READING
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