Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model

@inproceedings{Minas2017CombinedEO,
  title={Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model},
  author={Tsion Zewdu Minas and Didier Surdez and Tahereh Javaheri and Miwa Tanaka and Michelle Howarth and Hong-Jun Kang and Jenny Han and Zhi-Yan Han and Barbara Sax and Barbara E. Kream and Sung-Hyeok Hong and Haydar Çelik and Franck Tirode and Jan P Tuckermann and Jeffrey A Toretsky and Lukas Kenner and Heinrich Kovar and Sean Bong Lee and E Alejandro Sweet-Cordero and Takuro Nakamura and Richard Moriggl and Olivier Delattre and Aykut {\"U}ren},
  booktitle={Oncotarget},
  year={2017}
}
Ewing sarcoma (ES) involves a tumor-specific chromosomal translocation that produces the EWS-FLI1 protein, which is required for the growth of ES cells both in vitro and in vivo. However, an EWS-FLI1-driven transgenic mouse model is not currently available. Here, we present data from six independent laboratories seeking an alternative approach to express EWS-FLI1 in different murine tissues. We used the Runx2, Col1a2.3, Col1a3.6, Prx1, CAG, Nse, NEFL, Dermo1, P0, Sox9 and Osterix promoters to… CONTINUE READING
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