Combined enalapril and felodipine extended release (ER) for systemic hypertension. Enalapril-Felodipine ER Factorial Study Group.

@article{Gradman1997CombinedEA,
  title={Combined enalapril and felodipine extended release (ER) for systemic hypertension. Enalapril-Felodipine ER Factorial Study Group.},
  author={Alan H. Gradman and Neal R. Cutler and Peter Davis and James A. Robbins and Robert Jason Weiss and Benjamin C. Wood},
  journal={The American journal of cardiology},
  year={1997},
  volume={79 4},
  pages={431-5}
}
This multicenter, placebo-controlled, double-blind trial of factorial design evaluated the safety and efficacy of combination treatment with the angiotensin-converting enzyme inhibitor, enalapril, and the vascular selective calcium antagonist felodipine extended release (ER) in patients with essential hypertension. After a 4-week, single-blind placebo baseline period, 707 patients with sitting diastolic blood pressures (BPs) in the range of 95 to 115 mm Hg received placebo, enalapril (5 or 20… CONTINUE READING
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