Combined effects of the drug distribution and mucus diffusion properties of self‐microemulsifying drug delivery systems on the oral absorption of fenofibrate

@article{Sunazuka2018CombinedEO,
  title={Combined effects of the drug distribution and mucus diffusion properties of self‐microemulsifying drug delivery systems on the oral absorption of fenofibrate},
  author={Yushi Sunazuka and K. Ueda and K. Higashi and Yusuke Tanaka and K. Moribe},
  journal={International Journal of Pharmaceutics},
  year={2018},
  volume={546},
  pages={263–271}
}
Graphical abstract Figure. No Caption available. &NA; We present the absorption improvement mechanism of fenofibrate (FFB), a Biopharmaceutics Classification System (BCS) class II drug, from self‐microemulsifying drug delivery systems (SMEDDS), centered on improving the diffusion of FFB through the unstirred water layer (UWL). Four SMEDDS formulations containing Labrafac™ lipophile WL 1349 (WL1349) or Labrafil® M 1944CS (M1944) oils and NIKKOL HCO‐40 (HCO40) or NIKKOL HCO‐60 (HCO60) surfactants… Expand
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