Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: evidence from intracellular fluorescence and increased photodynamic efficacy in vitro.

@article{Dbrowski2012CombinedEO,
  title={Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: evidence from intracellular fluorescence and increased photodynamic efficacy in vitro.},
  author={Janusz M Dąbrowski and Luis G Arnaut and Mariette M Pereira and Krystyna M. Urbanska and S{\'e}rgio Sim{\~o}es and Grazyna Stochel and Lu{\'i}sa Cortes},
  journal={Free radical biology & medicine},
  year={2012},
  volume={52 7},
  pages={1188-200}
}
Sulfonamides of halogenated bacteriochlorins bearing Cl or F substituents in the ortho positions of the phenyl rings have adequate properties for photodynamic therapy, including strong absorption in the near-infrared (λ(max) ≈ 750 nm, ε ≈ 10(5) M(-1) cm(-1)), controlled photodecomposition, large cellular uptake, intracellular localization in the endoplasmic… CONTINUE READING