Combined effects of radiotherapy and endostatin gene therapy in melanoma tumor model

@article{Wu2008CombinedEO,
  title={Combined effects of radiotherapy and endostatin gene therapy in melanoma tumor model},
  author={De-sheng Wu and Cong-mei Wu and Tian-hua Huang and Q. Xie},
  journal={Radiation and Environmental Biophysics},
  year={2008},
  volume={47},
  pages={285-291}
}
PEgr–Endostatin–EGFP plasmid was constructed to investigate its expression properties induced by ionizing irradiation and the effect of pEgr–Endostatin–EGFP gene-radiotherapy on melanoma tumor-bearing mice. The pEgr–Endostatin–EGFP plasmid was transfected into B16 cell line with liposome. The expression property of endostatin was investigated by RT-PCR and that of EGFP was detected by flow cytometry. Tumor-bearing mice were treated by the plasmid injection and 2 Gy X-irradiation of three… Expand
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