Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model.

@article{Griscelli2000CombinedEO,
  title={Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model.},
  author={Frank Griscelli and Hong Li and Cheolho Cheong and Paule Opolon and Annelise Bennaceur-Griscelli and Gilles Vassal and Juan Jos{\'e} Garc{\'i}a Soria and Claudine Soria and He Min Lu and M. Perricaudet and C{\'e}cile Orsini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 12},
  pages={
          6698-703
        }
}
The objective of the present study was to evaluate the antitumor effect of a defective adenovirus expressing a secretable angiostatin-like molecule (AdK3) in combination with radiotherapy in rat C6 gliomas s.c. preestablished into athymic mice. In vitro, the combination regimen was significantly (P < 0.001) more cytotoxic for human microcapillary endothelial cells than either treatment alone, whereas survival of C6 glioma cells was not affected in the conditions used. Radiotherapy and AdK3 gene… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

Potential adenovirus-mediated gene therapy of glioma cancer

VIEW 3 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.

M ED IC A L SC IE N CE S

O. V. Solesvik, E. K. Rofstad, T. Brustad
  • Radiat. Res
  • 1984