Combined effects of psychostimulants and morphine on locomotor activity in mice.

@article{Mori2004CombinedEO,
  title={Combined effects of psychostimulants and morphine on locomotor activity in mice.},
  author={Tomohisa Mori and Shinobu Ito and Minoru Narita and Tsutomu Suzuki and Toshiko Sawaguchi},
  journal={Journal of pharmacological sciences},
  year={2004},
  volume={96 4},
  pages={450-8}
}
Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. This combination appears to produce synergistic effects on behavior at low doses; however, there is little direct evidence that the combination is stronger than either drug alone. Therefore, we investigated interactions between psychostimulants and morphine on locomotor activity in mice. Low doses of cocaine (5.0 mg/kg) or methamphetamine (0.5 mg/kg) and morphine (10 mg/kg) enhance locomotor… CONTINUE READING
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