Combined effects of oestrogen receptor antagonists on in vitro vitellogenesis.

  title={Combined effects of oestrogen receptor antagonists on in vitro vitellogenesis.},
  author={Karina Petersen and Knut Erik Tollefsen},
  journal={Aquatic toxicology},
Some environmental compounds are known to have anti-oestrogenic activity and their modes of action (MoA) are believed to include competitive inhibition of 17β-estradiol (E2) binding to the oestrogen receptor (ER) or interference with ER-dependent processes. The presence of multiple compounds having the same MoA may cause concern, as exposure to multiple compounds at concentrations below their threshold for effect can interact with cellular targets to cause effects in combination. The combined… CONTINUE READING
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