Combined effects of fenmetozole and ethanol

@article{Griffis1978CombinedEO,
  title={Combined effects of fenmetozole and ethanol},
  author={Larry C. Griffis and Thomas P. Bright and Benito J. Cerimele and Robert B. Forney},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1978},
  volume={24}
}
Eight male subjects took none or 200 mg fenmetozole 1 hr before drinking a beverage containing none or 50 m/l70 kg ethanol. Tests designed to measure mental and motor performance were administered 2 hr after fenmetozole ingestion. Fenmetozole alone impaired standing steadiness but improved mental performance in one test. Fenmetozole did not antagonize the decrement in performance induced by this amount of ethanol. In combination, the subjective symptoms caused by fenmetozole were additive with… 
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References

SHOWING 1-10 OF 14 REFERENCES
Fenmetozole in acute alcohol intoxication in man
TLDR
Pretreatment with fenmetozole failed to antagonize or attenuate cognitive, perceptual, motor and affective changes associated with acute alcohol intoxication.
Effects of marihuana combined with secobarbital
TLDR
Object and subjective tests designed to measure mental and motor performance indicated that marihuana impaired stability, hand‐eye coordination, and mental performance and secobarbital had an additive effect on subjective responses and impairment in certain psychomotor performance tests.
Impairment of performance with low doses of marihuana
TLDR
Analysis of variance revealed a significant linear decrease in stability with increase in dose of THC, and tracking scores with Pursuit Meter demonstrated a significant increase above control for all three doses of THC.
Selective Antagonism of Central Nervous System Depressants by DH-524; A Comparative Study with Bemegride
TLDR
Data suggest that DH-524 would be more selective and have a wider margin of safety than the commonly used analeptics in the treatment of barbiturate or methaqualone overdose.
Antagonism of Depressant Activity of Ethanol by DH-524; a Comparative Study with Bemegride, Doxapram and d-Amphetamine
  • A. Abdallah, D. Roby
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1975
TLDR
The purpose of this study was to compare the effects of DH-524 (2(3,4-dichlorophenoxy)-methyl-2-imidazoline), bemegride, doxapram and d-amphetamine on the narcotic and hypothermic effect of ethanol in mice.
A device for estimating stability of stance in human subjects.
TLDR
The apparatus was designed for use in testing drugs that may affect static balance when each S is used as his own control, and instability increased in the order of test 1, 2, 3, and 4 with most Ss, but in some, closing the eyes alone had little effect in reducing stability of stance.
Fenmetazole (DH-524): euphoriant classified by cerebral electrometry.
  • M. Fink, P. Irwin
  • Medicine
    Current therapeutic research, clinical and experimental
  • 1975
The antagonism of ethanol depression by 2 ( ( 3 , 4 - dichlorophenoxy ) - methyl ) - 2 - imidazoline hydrochloride
  • Toxicol Appl PharmacoI
  • 1977
Clinical trial of im - idazoline ( DH - 524 ) as an antidepressant
  • Curr Ther Res
  • 1971
Fomey RB: The antagonism of ethanol depression by 2((3,4-dichlorophenoxy)methyl)-2-imidazoline hydrochloride
  • Toxicol Appl PharmacoI41:169,
  • 1977
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