Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans.

@article{Qureshi1999CombinedEO,
  title={Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans.},
  author={Mahboob Hossain Qureshi and Tingting Christina Zhang and Yoshinobu Koguchi and Kosuke Nakashima and Hitoshi Okamura and Masashi Kurimoto and Kazuyoshi Kawakami},
  journal={European journal of immunology},
  year={1999},
  volume={29 2},
  pages={
          643-9
        }
}
We reported recently that interleukin (IL)-12 and IL-18 synergistically increased the fungicidal activity of mouse peritoneal exudate cells against Cryptococcus neoformans by inducing the production of interferon (IFN)-gamma by natural killer (NK) cells. To confirm these findings in vivo, we examined the effect of combined treatment using these two cytokines on the course of experimentally induced pulmonary and disseminated cryptococcosis in mice. IL-12 and IL-18 were used at subtherapeutic… CONTINUE READING

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Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment

F Gullo, S Rossi, +3 authors A. M. Fusco-Almeida
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