Combined effect of tnf-α polymorphisms and hypoxia on steroid-induced osteonecrosis of femoral head.

@article{Liu2015CombinedEO,
  title={Combined effect of tnf-α polymorphisms and hypoxia on steroid-induced osteonecrosis of femoral head.},
  author={Yaosheng Liu and Weihao Jiang and Shubin Liu and Xiu-yun Su and Shiguo Zhou},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 3},
  pages={3215-9}
}
OBJECTIVE Tumor necrosis factor (TNF)-α is a proinflammatory cytokine, some studies reported that TNF-α gene plays important role in the pathogenesis of SONFH. And the polymorphisms of TNF-α were presented as risk factors for steroid-induced osteonecrosis of the femoral head (SONFH). Meanwhile, various environment factors involve in the pathogenesis of SONFH. Our study aimed to investigate the interaction effect of TNF-α polymorphisms and hypoxia factor on SONFH. METHODS 120 patients with… CONTINUE READING
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