Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cells.

@article{Takei2000CombinedEO,
  title={Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cells.},
  author={Hiroshi Takei and Dominique P. Pioletti and S Y Kwon and K. L. Paul Sung},
  journal={Journal of biomedical materials research},
  year={2000},
  volume={52 2},
  pages={
          382-7
        }
}
  • Hiroshi Takei, Dominique P. Pioletti, +1 author K. L. Paul Sung
  • Published 2000
  • Materials Science, Medicine
  • Journal of biomedical materials research
  • To clarify the role of tumor necrosis factor (TNF)-alpha on osteoblast functions in the presence of metal particles, two human osteoblast-like cell lines (MG-63 and SaOS-2) were cultured with TNF-alpha in the presence or absence of titanium particles in vitro. A combination of TNF-alpha and titanium particles showed additive effects on inhibition of cell proliferation and alkaline phosphatase production. On the other hand, production of interleukin-6, which is well known to induce… CONTINUE READING

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