Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients.

@article{Bouzgarrou2011CombinedEO,
  title={Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients.},
  author={Nadia Bouzgarrou and E. Ben Hassen and Olfa Bahri and Sallouha Gabbouj and Nabyl Ben Mami and Hinda Triki and Lotfi Chouchane},
  journal={Hepatology international},
  year={2011},
  volume={5 2},
  pages={681-7}
}
PURPOSE Chronic hepatitis C progression is commonly attributed to the continuous activation of the immune response with an increased production of pro-inflammatory cytokines, leading to fibrosis and ultimately to cirrhosis. On the contrary, anti-inflammatory cytokines, mainly interleukin (IL)-10 have a modulatory effect on hepatic fibrogenesis. The association between individual polymorphisms within cytokine genes and hepatitis C outcome is often weak and non-informative. Interestingly, it has… CONTINUE READING
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A proinflammatory

  • JC Machado, C Figueiredo, +10 authors M. Sobrinho-Simões
  • Hepatol Int
  • 2011

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