Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.

@article{Baudoux2007CombinedEO,
  title={Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.},
  author={Pierre Baudoux and Nathalie Bles and Sandrine Lemaire and Marie-Paule Mingeot-Leclercq and Paul M Tulkens and Françoise Van Bambeke},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={59 2},
  pages={246-53}
}
BACKGROUND Staphylococcus aureus survives in acid media, including phagolysosomes. Conflicting in vitro/in vivo data exist on its susceptibility to antibiotics in such environments. METHODS Oxacillin and gentamicin activities against methicillin-susceptible S. aureus ATCC 25923 were compared extracellularly (broth; different pH) and assessed intracellularly (THP-1 macrophages), using a pharmacological approach (antibiotic concentrations: 0.01-1000 x MIC). Antibiotic cellular contents were… CONTINUE READING
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