Combined effect of HLA-DRB1<ce:sup loc=post>*</ce:sup>1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis

@article{Concha1997CombinedEO,
  title={Combined effect of HLA-DRB1<ce:sup loc=post>*</ce:sup>1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis},
  author={Emilio G{\'o}mez de la Concha and Rafael Arroyo and J. Bart A. Crusius and Jos{\'e} Antonio Campillo and Miguel Fern{\'a}ndez-Arquero},
  journal={Journal of Neuroimmunology},
  year={1997},
  volume={80},
  pages={172-178}
}
Ž . ) Susceptibility to multiple sclerosis MS is associated with HLA-DRB1 1501. Many reports have suggested associations with other Ž . loci but these results remain unconfirmed. We studied the IL-1 receptor antagonist IL-1ra gene polymorphism and the HLA-DR and DQ Ž . Ž allele frequencies by DNA-based methods in both the primary chronic progressive form PP MS and the relapsingrremitting form RrR . ) MS . The frequency of DRB1 1501 and IL-1ra allele 2 were significantly higher in RrR MS… CONTINUE READING

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