Combined dynamic light scattering and Raman spectroscopy approach for characterizing the aggregation of therapeutic proteins.

@article{Lewis2014CombinedDL,
  title={Combined dynamic light scattering and Raman spectroscopy approach for characterizing the aggregation of therapeutic proteins.},
  author={E. Neil Lewis and Wei Qi and Linda H. Kidder and Samiul Amin and Stacy M Kenyon and Steven Blake},
  journal={Molecules},
  year={2014},
  volume={19 12},
  pages={20888-905}
}
Determination of the physicochemical properties of protein therapeutics and their aggregates is critical for developing formulations that enhance product efficacy, stability, safety and manufacturability. Analytical challenges are compounded for materials: (1) that are formulated at high concentration, (2) that are formulated with a variety of excipients, and (3) that are available only in small volumes. In this article, a new instrument is described that measures protein secondary and tertiary… CONTINUE READING
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