Combined directed ortho metalation—intramolecular Friedel–Crafts connections. Regiospecific route to 1-substituted fluoren-9-ones

@inproceedings{Tilly2002CombinedDO,
  title={Combined directed ortho metalation—intramolecular Friedel–Crafts connections. Regiospecific route to 1-substituted fluoren-9-ones},
  author={David Tilly and Subhendu S. Samanta and Ferenc Faigl and Jacques Mortier},
  year={2002}
}
Abstract ortho -Substituted-2-biphenyl carboxylic acids of the type 3a – j were prepared by the tandem metalation sequence from 2-biphenyl carboxylic acid 1 with sec -butyllithium in THF at −78°C followed by quenching with electrophiles. The carboxylic acids 3a – f were converted into 1-substituted fluorenones 4a – f upon treatment with methanesulfonic acid.