Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer

  title={Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer},
  author={Yinying Wu and Y. Li and Xiaoai Zhao and D. Dong and C. Tang and E. Li and Q. Geng},
  journal={Oncology Letters},
  pages={129 - 136}
Molecular tumor markers hold considerable promise for accurately predicting the recurrence and progression of colorectal cancer (CRC) in patients. However, in the majority of cases, single marker analysis has been found to have low accuracy, and is of little practical use in clinical practice. The present study investigated the prognostic value of the combined detection of the protein expression of metastasis suppressor 23-H1 (Nm23-H1) and p53 using immunohistochemical analysis, and the mRNA… Expand
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Diagnosis and prognostic value of C-X-C motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort
  • Yi-Zhen Gong, Hui Ma, +11 authors Feng Gao
  • Medicine
  • Journal of Cancer
  • 2021
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Nm23-H1 expression does not predict clinical survival in colorectal cancer patients.
The results indicate that Nm23-H1 activity is tissue-specific and that in CRCs the expression of theprotein is not associated with tumor progression and patient prognosis, although further studies are required in order to throw more light on the possible clinical significance of the overexpression of the protein Nm 23-H 1 in such tumors. Expand
Down-expression pattern of Ku70 and p53 coexisted in colorectal cancer
The results showed that down-expression pattern of both Ku70 and p53 coexisted in the CRC samples with significant correlating rate (R2 = 0.9103; P <-0.001), and the down- expressions were significantly associated with the advanced tumor node metastasis stage. Expand
Prognostic effect of p53 expression in patients with completely resected colorectal cancer
Overall survival distribution and multivariable analysis by Cox regression model showed that p53 protein expression was an independent predictor of shorter overall survival in patients with completely resected CRC. Expand
[Expression of p53, bcl-2 and nm23 proteins in squamous cell lung cancer].
There is a marked heterogeneity of p53, bcl-2 and nm23 expression in squamous cell lung cancer and the potentially unfavorable influence of p 53 and bCl-2 coexpression is indicated. Expand
Expression of p 53 , bcl-2 and nm 23 proteins in squamous cell lung cancer
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Expression and Clinical Significances of p53 and Ki67 in Colorectal Carcinoma
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hMSH2 and nm23 expression in sporadic colorectal cancer and its clinical significance.
OBJECTIVE To study the expression of the mismatch repair proteins hMSH2 and nm23 in sporadic colorectal cancer, determine any inter-relationship, and further investigate any clinical significance. Expand
Prognostic Significance of Multiple Molecular Markers for Patients With Stage II Colorectal Cancer Undergoing Curative Resection
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The joint detection of VEGF-C and nm23-H1 expression is very promising in prediction of the prognosis of patients with stage II and III colorectal carcinoma, however, whether it can be used as a marker in prognosis judgment needs further investigation. Expand
The Relationship between the Expression of MMP-2 and p53 and Tumor′s Invasion and Metastasis in Colorectal Carcinoma
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