Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity.

@article{Lin2006CombinedDO,
  title={Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity.},
  author={En-Ju D. Lin and Amanda Sainsbury and Nicola J. Lee and Dana Boey and Michelle Couzens and Ronaldo F. Enriquez and Katy Slack and Ross Bland and Matthew John During and Herbert Herzog},
  journal={Endocrinology},
  year={2006},
  volume={147 11},
  pages={5094-101}
}
Neuropeptide Y (NPY) is a key regulator of energy homeostasis and is implicated in the development of obesity and type 2 diabetes. Whereas it is known that hypothalamic administration of exogenous NPY peptides leads to increased body weight gain, hyperphagia, and many hormonal and metabolic changes characteristic of an obesity syndrome, the Y receptor(s) mediating these effects is disputed and unclear. To investigate the role of different Y receptors in the NPY-induced obesity syndrome, we used… CONTINUE READING

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