Combined cytosine deaminase expression, 5-fluorocytoiine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells


Cholangiocarcinoma is a malignancy that is resistant to current therapy. We applied the toxin gene therapy strategy of cytosine deaminase conversion of the nontoxic prodrug 5-fluorocytosine to 5-fluorouracil combined with radiotherapy to cholangiocarcinoma. The transduction efficiency of SK-ChA-1 cholangiocarcinoma cells was determined by fluorescence… (More)
DOI: 10.1016/S1091-255X(98)80024-3


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