Combined correlation-based network and mQTL analyses efficiently identified loci for branched-chain amino acid, serine to threonine, and proline metabolism in tomato seeds.

@article{Toubiana2015CombinedCN,
  title={Combined correlation-based network and mQTL analyses efficiently identified loci for branched-chain amino acid, serine to threonine, and proline metabolism in tomato seeds.},
  author={David Toubiana and Albert Batushansky and Oren Tzfadia and Federico Scossa and Asif Khan and Simon Barak and Daniel Zamir and Alisdair R. Fernie and Zoran Nikoloski and Aaron Fait},
  journal={The Plant journal : for cell and molecular biology},
  year={2015},
  volume={81 1},
  pages={121-33}
}
Correlation-based network analysis (CNA) of the metabolic profiles of seeds of a tomato introgression line mapping population revealed a clique of proteinogenic amino acids: Gly, Ile, Pro, Ser, Thr, and Val. Correlations between profiles of these amino acids exhibited a statistically significant average correlation coefficient of 0.84 as compared with an average correlation coefficient of 0.39 over the 16 119 other metabolite cliques containing six metabolites. In silico removal of cliques was… CONTINUE READING
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