Combined cord blood stem cells and gene therapy enhances angiogenesis and improves cardiac performance in mouse after acute myocardial infarction.

@article{Chen2005CombinedCB,
  title={Combined cord blood stem cells and gene therapy enhances angiogenesis and improves cardiac performance in mouse after acute myocardial infarction.},
  author={H K Chen and H F Hung and Kou-Gi Shyu and Bao Wei Wang and J R Sheu and Yang Jiang Liang and Cheng Chang Chang and Peiliang Kuan},
  journal={European journal of clinical investigation},
  year={2005},
  volume={35 11},
  pages={677-86}
}
BACKGROUND Gene and stem cell therapies hold promise for the treatment of ischaemic cardiovascular disease. However, combined stem cell and angiogenic growth factor gene therapy for acute ischaemic myocardium has not been previously reported. This study hypothesized that combined stem cell and gene therapy would not only augment new vessels formation but also improve myocardial function in acute ischaemic myocardium. METHODS Human angiopoietin-1 (Ang1) cDNA and VEGF(165) cDNA were ligated… CONTINUE READING

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