Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7.

@article{Boulay2001CombinedCS,
  title={Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7.},
  author={J l Boulay and Gabriele Mild and J{\"u}rgen Reuter and Magali Lagrange and Luigi Maria Terracciano and Adam Lowy and Urban Laffer and Boris Orth and Ute Metzger and Bettina Stamm and Sara Martinoli and Richard Herrmann and Christoph Rochlitz},
  journal={Genes, chromosomes & cancer},
  year={2001},
  volume={31 3},
  pages={240-7}
}
Deletions of chromosome band 18q21 appear with very high frequency in a variety of carcinomas, especially in colorectal cancer. Potent tumor suppressor genes located in this region encode transforming growth factor beta (TGF-beta) signal transducers SMAD2 and SMAD4, and inactivation of either one leads to impaired TGF-beta-mediated cell growth/apoptosis. Following the assignment of SMAD7 to 18q21, we first refined the SMAD7 gene position within this region by genetically mapping SMAD7 between… CONTINUE READING

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