Combined chemotherapy and radiation with selective organ preservation for muscle-invasive bladder carcinoma. A single-institution phase II study.

@article{Fellin1997CombinedCA,
  title={Combined chemotherapy and radiation with selective organ preservation for muscle-invasive bladder carcinoma. A single-institution phase II study.},
  author={Gianni Fellin and Umberto Graffer and Andrea Bolner and Giovanni Ambrosini and Orazio Caffo and Lucio Luciani},
  journal={British journal of urology},
  year={1997},
  volume={80 1},
  pages={44-9}
}
OBJECTIVE To assess in a phase II trial the effectiveness and toxicity of combined chemotherapy and radiation with selective bladder preservation by response in the treatment of muscle-invasive bladder carcinoma. PATIENTS AND METHODS Fifty-six eligible patients with T2-4 M0 transitional cell bladder cancer suitable for radical surgery and multi-agent chemotherapy received two courses of methotrexate, cisplatin and vinblastine, followed by 40 Gy of pelvic radiotherapy in 1.8 Gy fractions with… CONTINUE READING

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