Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the Eastern Cooperative Oncology Group.

@article{Smith1998CombinedCV,
  title={Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the Eastern Cooperative Oncology Group.},
  author={Thomas James Smith and Louise M.. Ryan and Harold O. Douglass and Daniel G. Haller and Yogeshwar Dayal and John Kirkwood and Douglass C. Tormey and Allan J. Schutt and Jeffrey Hinson and Benjamin Sischy},
  journal={International journal of radiation oncology, biology, physics},
  year={1998},
  volume={42 2},
  pages={269-76}
}
Squamous carcinoma of the thoracic esophagus has an extremely poor prognosis. This study, EST-1282, was undertaken by the Eastern Cooperative Oncology Group (ECOG) to determine whether the combined use of 5-fluorouracil (5-FU), mitomycin C, and radiation therapy improved the disease-free survival and overall survival of patients with carcinoma of the esophagus, compared to those who received radiation therapy alone. Two- and 5-year survivals were 12% and 7% in the radiation alone arm and 27… CONTINUE READING

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