Combined chemoassay and mass spectrometric approach to study the reactive potential of electrophiles towards deoxynucleosides as model for DNA.

Abstract

The modification of DNA by adduct formation is a potential molecular initiating event of genotoxicity. A chemoassay was established to study adduct formation of electrophiles with deoxynucleosides. Liquid chromatography-mass spectrometry was used to determine the reactivity of the model electrophiles para-benzoquinone, hydroquinone, and 1,4-naphthoquinone… (More)
DOI: 10.1016/j.chemosphere.2016.02.052

Topics

Cite this paper

@article{SchmiedTobies2016CombinedCA, title={Combined chemoassay and mass spectrometric approach to study the reactive potential of electrophiles towards deoxynucleosides as model for DNA.}, author={Maria I H Schmied-Tobies and Heidrun Paschke and Thorsten Reemtsma}, journal={Chemosphere}, year={2016}, volume={151}, pages={263-70} }