Combined chemo- and immunotherapy of tumors induced in mice by bcr-abl-transformed cells.

@article{Sobotkov2009CombinedCA,
  title={Combined chemo- and immunotherapy of tumors induced in mice by bcr-abl-transformed cells.},
  author={Eva Sobotkov{\'a} and Martina Du{\vs}kov{\'a} and Ruth Tachezy and Martina Petr{\'a}{\vc}kov{\'a} and Vladim{\'i}r Vonka},
  journal={Oncology reports},
  year={2009},
  volume={21 3},
  pages={793-9}
}
For our experiments we selected two oncogenic, bcr-abl-transformed mouse cell lines, viz. B210 and 12B1. Both cell types are capable of inducing leukemia-like disease in syngeneic BALB/c mice after intravenous inoculation. 12B1 cells can moreover form solid tumors after subcutaneous injection. Since immunotherapy would expectedly be most effective in animals in which the tumor mass had been reduced by other therapeutic means, we attempted to develop a combined therapeutic system for suppressing… CONTINUE READING

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