Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts

@inproceedings{Dunn2016CombinedCI,
  title={Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts},
  author={S.-J. Dunn and James M. Osborne and Paul L. Appleton and Inke S. N{\"a}thke},
  booktitle={Molecular biology of the cell},
  year={2016}
}
Curative intervention is possible if colorectal cancer is identified early, underscoring the need to detect the earliest stages of malignant transformation. A candidate biomarker is the expanded proliferative zone observed in crypts before adenoma formation, also found in irradiated crypts. However, the underlying driving mechanism for this is not known… CONTINUE READING