Combined blockade of renin-angiotensin-aldosterone system reduced all-cause but not cardiovascular mortality in dialysis patients: A mediation analysis and systematic review.

@article{Li2018CombinedBO,
  title={Combined blockade of renin-angiotensin-aldosterone system reduced all-cause but not cardiovascular mortality in dialysis patients: A mediation analysis and systematic review.},
  author={Shao-min Li and Wan-Bing He and Jie Chen and Qing-qing Cai and Feifei Huang and Kun Zhang and Jing-Feng Wang and Xun Liu and Hui Huang},
  journal={Atherosclerosis},
  year={2018},
  volume={269},
  pages={
          35-41
        }
}
BACKGROUND AND AIMS Full blockade of renin-angiotensin-aldosterone system (RAAS) is believed to decrease morbidity and mortality of patients with chronic kidney disease. In non-dialysis patients, combined RAAS blockade with two different RAAS blockers causes more adverse events without improving survival, but its role in maintenance dialysis patients is still unclear. We conducted a systematic review and mediation analysis to investigate the efficacy and safety of combined RAAS blockade in… CONTINUE READING

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