Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.

@article{Fisicaro2012CombinedBO,
  title={Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.},
  author={Paola Fisicaro and Caterina Valdatta and Marco Massari and Elisabetta Loggi and Lara Ravanetti and Simona Urbani and Tiziana Giuberti and Albertina Cavalli and Carmen Vandelli and Pietro Andreone and Gabriele Missale and Carlo Ferrari},
  journal={Gastroenterology},
  year={2012},
  volume={143 6},
  pages={1576-1585.e4}
}
BACKGROUND & AIMS In patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, antiviral functions of T cells are impaired; these might be increased by blocking T-cell co-inhibitory pathways, such as preventing interaction between the receptor programmed death (PD)-1 and its ligand, PD-L1. We attempted to optimize the restoration of T-cell functions in patients with chronic HBV or HCV infection with a combination of reagents that block PD-1 interaction with PD-L1 and… CONTINUE READING
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Dual function of the NK cell receptor 2 B 4 ( CD 244 ) in the regulation of HCV - specific CD 8  T cells

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