Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species.

@article{Hsieh2011CombinedAA,
  title={Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species.},
  author={Bau-Shan Hsieh and Li-Wen Huang and Shu-Jem Su and Hsiao-Ling Cheng and Yu-Chen Hu and Thu-Ching Hung and Kee-Lung Chang},
  journal={The Journal of nutritional biochemistry},
  year={2011},
  volume={22 3},
  pages={234-41}
}
Arginine is a physiological substrate for nitric oxide synthase to generate nitric oxide (NO), which can influence tumor cell survival, while ascorbic acid is selectively toxic for cancer cells. This study explored the effect of an arginine/ascorbic acid combination on human cancer cell lines. The hepatoma cell line HA22T/VGH was the most sensitive of the tested cells to combination treatment. A combination of 5.74 mM of arginine and 0.57 mM of ascorbic acid induced HA22T/VGH cell death through… CONTINUE READING