Combined antiviral effect of DNA inhibitors on adenovirus multiplication.


9 purine or pyrimidine analogues or other inhibitors of DNA synthesis were studied on their single and combined inhibitory effect on the multiplication of adenovirus 9--15 in HeLa cell cultures. The criterium of inhibition was the total suppression of the formation of infectious virus. Inhibiting concentrations were derived from isobolograms. 34 of 36 drug pairs acted in a synergistic manner, one pair showed additive and one no interaction.


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@article{Wirjawan1978CombinedAE, title={Combined antiviral effect of DNA inhibitors on adenovirus multiplication.}, author={E Wirjawan and Reinhard Wigand}, journal={Chemotherapy}, year={1978}, volume={24 6}, pages={347-53} }