Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation.

  title={Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation.},
  author={Perenlei Enkhbaatar and Aimalohi Esechie and Jianpu Wang and Robert Ashley Cox and Yoshimitsu Y. Nakano and Atsumori Hamahata and Matthias Lange and Lillian D. Traber and Donald S. Prough and David N. Herndon and Daniel Lee Traber},
  journal={Clinical science},
  volume={114 4},
Burn and smoke inhalation-related multiple organ dysfunction is associated with a severe fall in the plasma concentration of antithrombin. Therefore the aim of the present study was to test the hypothesis that intravenous administration of recombinant human antithrombin in combination with aerosolized heparin will ameliorate acute lung injury in sheep exposed to cutaneous burn and smoke inhalation. Sheep were prepared operatively for study and, 7 days post-surgery, sheep were given a cutaneous… 

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