Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial

@inproceedings{Warde2011CombinedAD,
  title={Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial},
  author={Padraig Richard Warde and Malcolm David Mason and Keyue Ding and Peter Kirkbride and Michael Donald Brundage and R. A. Cowan and Mary Krystyna Gospodarowicz and Karen Sanders and Edmund C. Kostashuk and Greg Swanson and J. Barber and Andrea Hiltz and Mahesh K. B. Parmar and Jinka R Sathya and John B Anderson and Charles R R Hayter and John W Hetherington and Matthew R. Sydes and Wendy R. Parulekar},
  booktitle={The Lancet},
  year={2011}
}
BACKGROUND Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer. METHODS Patients with: locally advanced (T3 or T4) prostate cancer (n=1057); or organ-confined disease (T2) with either a prostate-specific antigen (PSA) concentration more than 40 ng/mL (n=119) or PSA concentration more… CONTINUE READING
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