Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer.

@article{Chen2010CombinedAO,
  title={Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer.},
  author={Jinn-Shiun Chen and Kuei-Tien Chen and Wen-Chun Fan and Jau-Song Yu and Yu-sun Chang and Err-Cheng Chan},
  journal={Clinical chemistry and laboratory medicine},
  year={2010},
  volume={48 5},
  pages={
          719-25
        }
}
BACKGROUND Survivin is a member of the family of inhibitor of apoptosis proteins that is overexpressed in several human tumors. Previous studies have found that overexpression of survivin in cancer cells induces an antibody response. METHODS We compared 232 serum samples from colorectal cancer (CRC) patients and 365 samples from healthy volunteers using an in vitro enzyme-linked immunosorbent assay to evaluate the survivin autoantibody response in patients. RESULTS The sensitivity of the… CONTINUE READING
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