Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.

@article{Zlobec2010CombinedAO,
  title={Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.},
  author={Inti Zlobec and Michal B. Kovac and Priska Erzberger and Francesca Molinari and Michel P. Bihl and Alexander Rufle and Anja Foerster and Milo Frattini and Luigi Maria Terracciano and Karl Heinimann and Alessandro Lugli},
  journal={International journal of cancer},
  year={2010},
  volume={127 11},
  pages={2569-75}
}
Confounding effects of specific KRAS gene alterations on colorectal cancer (CRC) prognosis stratified by microsatellite instability (MSI) and BRAF(V600E) have not yet been investigated. The aim of our study was to evaluate the combined effects of MSI, BRAF(V600E) and specific KRAS mutation (Gly → Asp; G12D, Gly → Asp, G13D; Gly → Val; G12V) on prognosis in 404 sporadic and 94 hereditary CRC patients. MSI status was determined according to the Bethesda guidelines. Mutational status of KRAS and… CONTINUE READING

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