Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.

Abstract

Confounding effects of specific KRAS gene alterations on colorectal cancer (CRC) prognosis stratified by microsatellite instability (MSI) and BRAF(V600E) have not yet been investigated. The aim of our study was to evaluate the combined effects of MSI, BRAF(V600E) and specific KRAS mutation (Gly → Asp; G12D, Gly → Asp, G13D; Gly → Val; G12V) on prognosis in… (More)
DOI: 10.1002/ijc.25265

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Cite this paper

@article{Zlobec2010CombinedAO, title={Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.}, author={Inti Zlobec and Michal Kov{\'a}c and Priska Erzberger and Francesca Molinari and Michel P. Bihl and Alexander Rufle and Anja F{\"o}rster and Milo Frattini and Luigi Maria Terracciano and Karl Heinimann and Alessandro Lugli}, journal={International journal of cancer}, year={2010}, volume={127 11}, pages={2569-75} }