Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.

@article{Ellinghaus2012CombinedAO,
  title={Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.},
  author={David Ellinghaus and Eva Ellinghaus and Rajan P. Nair and Philip E Stuart and T{\"o}nu Esko and Andres Metspalu and Sophie Debrus and John V. Raelson and T. Naga Sai Tejasvi and Majid Belouchi and Sarah L. West and Jonathan N. W. N. Barker and Sulev K{\~o}ks and K{\"u}lli Kingo and Tobias Balschun and Orazio Palmieri and Vito Annese and Christian Gieger and H. E. Wichmann and Michael Kabesch and Richard C Trembath and Christopher G Mathew and Gonçalo R. Abecasis and Stephan Weidinger and Susanna Nikolaus and Stefan Schreiber and James T. Elder and Michael Weichenthal and Michael Nothnagel and Andre Franke},
  journal={American journal of human genetics},
  year={2012},
  volume={90 4},
  pages={636-47}
}
Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their shared genetic causes. We performed meta-analyses of five published genome-wide association studies on PS (2,529 cases and 4,955 controls) and CD (2,142 cases and 5,505 controls), followed up 20 loci that showed strongest evidence for shared disease association and, furthermore, tested cross-disease associations for previously reported PS… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS