Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome.

@article{Stabile2011CombinedAO,
  title={Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome.},
  author={Laura P. Stabile and Sanja Dacic and Stephanie R. Land and Diana E. Lenzner and Rajiv Dhir and Marie B Acquafondata and Rodney J. Landreneau and Jennifer R Grandis and Jill M. Siegfried},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 1},
  pages={154-64}
}
PURPOSE Steroid hormones and growth factors affect lung cancer, and it is possible they act in concert to influence patient outcome. EXPERIMENTAL DESIGN Primary lung tumors and normal lung tissue were analyzed for expression and localization of estrogen receptor α and β-1 (ERα and ERβ), aromatase, progesterone receptor (PR), and epidermal growth factor receptor (EGFR). RESULTS Tumors expressed higher levels of ERβ compared to matched normal lung, whereas the reverse was true of PR. High… CONTINUE READING
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