Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes

  title={Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes},
  author={Mamoru Tochigi and Takeshi Otowa and Hiroyuki Hibino and Chieko Kato and Toshiyuki Otani and Tadashi Umekage and Takeshi Utsumi and Nobumasa Kato and Tsukasa Sasaki},
  journal={Neuroscience Research},

Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals

Association Between a Functional Polymorphism in the Monoamine Oxidase A (MAOA) Gene and Both Emotional Coping Style and Neuroticism

The current findings are novel in terms of being the first report of a relationship between a functional polymorphism in the MAOA gene and coping and add evidence to the association of this gene with neuroticism.

Tyrosine Hydroxylase and DOPA Decarboxylase Gene Variants in Personality Traits

No strong evidence was found for the associations between personality and TH or DDC in overall tests, and an interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters.

No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects

It is suggested that the (TCAT)n repeat polymorphism in the TH gene does not contribute to the personality traits evaluated on the TCI in healthy Japanese subjects.

Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior

A role of the COMT Val158Met polymorphism in smoking behavior in Japanese individuals may suggest a role for the MAO genes and smoking behavior, including epistatic or additive effects.

Genetic modulation of personality traits: a systematic review of the literature

No clear consensus on the role of any individual gene variant in personality modulation emerged, although SLC6A4 haplotypes and the DRD4 rs1800955 promoter variant seemed to be more reliably related to anxiety and impulsivity-related traits, respectively.

ABO Blood Type and Personality Traits in Healthy Japanese Subjects

A significant association between ABO blood group genotypes and personality traits in a large number of healthy Japanese subjects is observed, but these results should be regarded as preliminary and should be interpreted with caution because it is possible that the association between the ABOBlood group genotype and the Persistence trait is relatively weak.



Polymorphisms in the Serotonin Transporter and Monoamine Oxidase A Genes and Their Relationship to Personality Traits Measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in Healthy Volunteers

The results do not confirm the hypothesis that there is a simple correlation between single gene polymorphisms and a personality trait measured by the TCI and NEO-FFI scales.

A Regulatory Monoamine Oxidase A Promoter Polymorphism and Personality Traits

It is concluded that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population.

Lack of association between the functional variant of the catechol-o-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior.

The results suggest that COMT genotype has no major role in the development of early-onset alcoholism with severe antisocial behavior.

Genetic variants implicated in personality: A review of the more promising candidates

  • J. SavitzR. Ramesar
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2004
Both the theoretical and the empirical evidence implicating specific loci—in particular SERT and DRD4—in the development of personality is evaluated, and the existence of a genuine effect is argued for.

Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism

The results of the present study suggest that an inherited difference in catecholamine metabolism is important in the pathogenesis of anxiety in women.