Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype.

@article{Lerer2005CombinedAO,
  title={Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype.},
  author={Bernard Lerer and Ronnen H. Segman and Ene-Choo Tan and V S Basile and Roberto Cavallaro and Harald Nikolaus Aschauer and Rael David Strous and S Chong and Uriel Heresco-Levy and Massimiliano Verga and Joachim Scharfetter and Herbert Y Meltzer and James L Kennedy and Fabio Macciardi},
  journal={The international journal of neuropsychopharmacology},
  year={2005},
  volume={8 3},
  pages={411-25}
}
Tardive dyskinesia (TD) is an important limiting factor in the use of typical antipsychotic drugs. Genetic variability in the serotonin 2A (5-HT(2A)) receptor may influence risk for TD but the results of prior studies are not confirmatory. The objective of this study was to determine association of T102C and His452Tyr polymorphisms in the 5-HT(2A) receptor gene (HTR(2A)) with TD in a large, multicentre patient sample. The design employed case-control analysis controlling for possible… CONTINUE READING

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