Combined alpha-methylacyl coenzyme A racemase/p53 analysis to identify dysplasia in inflammatory bowel disease.

@article{Marx2009CombinedAC,
  title={Combined alpha-methylacyl coenzyme A racemase/p53 analysis to identify dysplasia in inflammatory bowel disease.},
  author={Andreas H Marx and Timo Wandrey and Philipp Simon and Agatha Wewer and Tobias J. Grob and Uta Reichelt and Sarah J P Minner and Ronald Simon and Martina E. Spehlmann and Wolfgang Tigges and Nib Soehendra and Uwe Seitz and Stefan Seewald and Jakob Robert Izbicki and Emre F. Yekebas and Jussuf Thomas Kaifi and Martina Mirlacher and Luigi Maria Terracciano and Achim Fleischmann and Andreas Raedler and Guido Sauter},
  journal={Human pathology},
  year={2009},
  volume={40 2},
  pages={
          166-73
        }
}
Identification of dysplasia in inflammatory bowel disease represents a major challenge for both clinicians and pathologists. Clear diagnosis of dysplasia in inflammatory bowel disease is sometimes not possible with biopsies remaining "indefinite for dysplasia." Recent studies have identified molecular alterations in colitis-associated cancers, including increased protein levels of alpha-methylacyl coenzyme A racemase, p53, p16 and bcl-2. In order to analyze the potential diagnostic use of these… CONTINUE READING
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