Combined age- and trauma-related proteomic changes in rat neocortex: a basis for brain vulnerability.

@article{Mehan2012CombinedAA,
  title={Combined age- and trauma-related proteomic changes in rat neocortex: a basis for brain vulnerability.},
  author={Neal D Mehan and Kenneth I. Strauss},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 9},
  pages={1857-73}
}
This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and recover less cognitive and neurologic function than younger victims. Utilizing a rat traumatic brain injury model, sham surgery or a neocortical contusion was induced in 3 age groups. Geriatric (21 months) rats performed worse on behavioral measures than young adults (12-16 weeks) and juveniles (5-6 weeks). Motor coordination and certain cognitive… CONTINUE READING
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