Combined administration of desipramine and reserpine or tetrabenazine in depressive patients

Patients resistant to imipramine or desipramine could be made responsive to the drug by some injections of reserpine of tetrabenazine. This observation calls to mind animal experiments in which the typical reserpine-syndrome can be antagonized by pretreatment with imipramine or, in a more specific way and with a quicker onset of action, by desipramine. With… (More)