Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue

Abstract

Methylene blue (MB) delays cellular senescence, induces complex-IV, and activates Keap1/Nrf2; however, the molecular link of these effects to MB is unclear. Since MB is redox-active, we investigated its effect on the NAD/NADH ratio in IMR90 cells. The transient increase in NAD/NADH observed in MB-treated cells triggered an investigation of the energy… (More)
DOI: 10.1016/j.redox.2015.09.004

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