Combined Wnt/β-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.

@article{Holland2013CombinedWM,
  title={Combined Wnt/β-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.},
  author={Jane D. Holland and Balazs Gy{\"o}rffy and Regina Vogel and Klaus Eckert and Giovanni Valenti and Liang Fang and Philipp Lohneis and Sefer Elezkurtaj and Ulrike Ziebold and Walter Birchmeier},
  journal={Cell reports},
  year={2013},
  volume={5 5},
  pages={1214-27}
}
Prognosis for patients with estrogen-receptor (ER)-negative basal breast cancer is poor, and chemotherapy is currently the best therapeutic option. We have generated a compound-mutant mouse model combining the activation of β-catenin and HGF (Wnt-Met signaling), which produced rapidly growing basal mammary gland tumors. We identified the chemokine system CXCL12/CXCR4 as a crucial driver of Wnt-Met tumors, given that compound-mutant mice also deficient in the CXCR4 gene were tumor resistant. Wnt… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 67 references

b-Catenin pathway

F. C. Geyer, M. Lacroix-Triki, +5 authors J. S. Reis-Filho
2011
View 2 Excerpts
Highly Influenced

Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2010
View 2 Excerpts
Highly Influenced

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