Combined Transfection of the Three Transcriptional Factors, PDX-1, NeuroD1, and MafA, Causes Differentiation of Bone Marrow Mesenchymal Stem Cells into Insulin-Producing Cells

@inproceedings{QingSong2012CombinedTO,
  title={Combined Transfection of the Three Transcriptional Factors, PDX-1, NeuroD1, and MafA, Causes Differentiation of Bone Marrow Mesenchymal Stem Cells into Insulin-Producing Cells},
  author={Guo Qing-Song and Zhu Ming-Yan and Wang Lei and Fan Xiang-Jun and Lu Yu-Hua and Wang Zhi-wei and Zhu Sha-Jun and W Lei Yao and Huang Yan},
  booktitle={Experimental diabetes research},
  year={2012}
}
AIMS The goal of cell transcription for treatment of diabetes is to generate surrogate β-cells from an appropriate cell line. However, the induced replacement cells have showed less physiological function in producing insulin compared with normal β-cells. METHODS Here, we report a procedure for induction of insulin-producing cells (IPCs) from bone marrow murine mesenchymal stem cells (BM-mMSCs). These BM-mMSCs have the potential to differentiate into insulin-producing cells when a combination… CONTINUE READING
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